It’s a genetic disease, but most cases aren’t thought to be hereditary. Myelodysplastic syndromes (MDSs) Myeloproliferative neoplasms (MPNs) Leukemia is a cancer that starts in the stem cells of the blood. 4. Leukemia starts in the bone marrow, so checking the bone marrow for leukemia cells is a key part of testing for it. ALL is the most common type of cancer in children. cancer of the blood, leucaemia, leukaemia. Acute leukaemias have a rapid onset and progression and are invariably fatal if left untreated. In rare and more advanced cases, CLL can affect the central. Summary. 5,000–10,000. The hallmark of ALL is chromosomal abnormalities and genetic alterations involved in differentiation and proliferation of lymphoid precursor cells. • Treatments include chemotherapy, radiation, stem cell transplant, surgery, immunotherapy. People usually don't realize there's anything wrong at first. These tear drop cells are found primarily in diseases with bone marrow fibrosis, such as: primary myelofibrosis, myelodysplastic. Most people with CML have a gene mutation (change) called the. Acute myeloid leukemia is an aggressive cancer that can be life-threatening. But to make sure this research leads to safe and innovative. 4. Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. Learn more about the types, symptoms, diagnosis, and treatment of leukemia. Abnormally high or low levels of MCH, as determined by blood testing, can be an. [2] Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. The bottom line. The most common symptom is a very high white blood cell count. Doctors base leukemia staging on the amount of cancerous white blood cells in the body. Hemoglobin is the substance that carries oxygen from the lungs, to the cells through the bloodstream. AML usually affects people age 60 and older, but it can also affect younger adults and children. There are 3 main types of marginal zone lymphomas: Extranodal marginal zone B-cell lymphoma, also known as mucosa-associated lymphoid tissue (MALT) lymphoma: This is the most common type of marginal zone lymphoma. Enlargement of the spleen and low red blood cells may also. Karloff. KC presenting to the emergency room unconscious. Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells. Leukemia is a type of cancer found in your blood and bone marrow and is caused by the rapid production of abnormal white blood cells. The most common symptom is a very high white blood cell count. Bone or joint pain. • Process takes two to four hours and is similar to a regular blood donation. For personalized disease and treatment information, or to learn about clinical trials, contact one of The Leukemia & Lymphoma Society's (LLS's) Information Specialists at (800) 955-4572. Pathophysiology. These are not just symptoms of AML. Infections: This is one of the most common causes of skin rashes in leukemia patients. FDA has approved zanubrutinib (Brukinsa) for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) based on results from two clinical trials. AML usually begins in cells that turn into white blood cells, but it can start. Ani is short for Anakin and Chewie is short for Chewbacca. The NHS provides more information on leukaemia symptoms and blood cancer symptoms, broken down by leukaemia type. When you have leukemia, your body makes too many blood cells, which are abnormal. Signs and symptoms of chronic myelogenous leukemia include weight loss and tiredness. Leukemia can be either acute or chronic. A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. They are characterized by an accumulation of early haemopoietic cells, known as blast cells (see Fig. They may happen if the initial treatment doesn’t eliminate all. It happens when cancerous cells enter the skin and cause lesions. The virus can cause adult T-cell leukaemia/lymphoma (ATL) and progressive nervous system condition known as HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP). chronic fever. Acute lymphocytic leukemia (ALL) is a cancer of the blood and bone marrow. SEER is an authoritative source for cancer statistics in the United States. Shortness of breath. White blood cells (leukocytes) are used by the body to fight infections and other foreign substances. People are often diagnosed with leukemia when their doctor finds abnormal blood counts during a routine physical exam. Acute monocytic leukemia (AMoL) is a subtype of acute myeloid leukemia (AML). When you have cancer, you will probably need regular lab, imaging, or other tests. Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). A marked increase of dacrocytes is known as dacrocytosis. Bone pain (caused by leukemia cells spreading from the marrow cavity to the surface of the bone or into the joint)This can cause more or abnormal bleeding and bruising, such as bleeding gums or nosebleeds. Risk factors for AML include: Advanced age. Ans. It can sometimes spread to other parts of the body including the lymph nodes, liver, spleen, central nervous system (brain and spinal cord), and testicles. Male sex. Mean corpuscular hemoglobin concentration (MCHC) measures the concentration of hemoglobin in red blood cells. It happens when blood cells. 0. This is a smart joke and I like it. Chills. The type of leukemia depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. Chemotherapy (chemo) is the main treatment for most types of AML, although. AML is a type of cancer that goes by several other names, such as acute myeloid leukemia, acute myelocytic leukemia, acute myelogenous leukemia, acute granulocytic leukemia, or acute non-lymphocytic leukemia. It is more common in children than in adults. 2. There are different types of leukemia. When ALL spreads to the chest, shortness of breath, and a cough may occur. Synonyms. • Symptoms include fever, chills, fatigue, weakness, weight loss, bone and joint pain, anemia. “There are many ways people can be immunocompromised,” says Stuart Seropian, MD, a Smilow Cancer Hospital. For personalized disease and treatment information, or to learn about clinical trials, contact one of The Leukemia & Lymphoma Society's (LLS's) Information Specialists at (800) 955-4572. fevers with no other symptoms. 2. Frequent infections. Normal myeloid cells develop into red blood cells, white blood cells and platelets. The Surveillance, Epidemiology, and End Results (SEER) Program provides information on cancer statistics in an effort to reduce the cancer burden among the U. Morphologically, acute leukaemia is defined as the presence of > 20% blast cells in the bone marrow or peripheral blood. Anatomy of the bone. Leukemia is a cancer that starts in the blood-forming cells of the bone marrow. Symptoms of low platelet count (thrombocytopenia), such as easy bruising and unexplained bleeding. Instead, a variety of risk. 5 % of red blood cells (up to 2. CML staging. From IMDb: Princess Leia:. Widespread vaccination has led to an overall decrease in leukemia cases. Some of the initial symptoms include. A fast or unusual heartbeat. Headache and other neurological symptoms. It is more common in children than in adults. Cancer is a disease of the cells in the body. Leukemia starts in blood-forming tissues such as the bone marrow. Leukemia leads to an uncontrolled increase in the number of white blood cells. People with AML often have several non-specific (general) symptoms. Acute leukaemia means it progresses quickly and aggressively, and usually requires immediate treatment. This cancer occurs primarily in older individuals, with a median age of diagnosis. What is Luke short for? : r/AntiJokes. Chronic lymphocytic leukemia ( CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). Acute lymphocytic (or lymphoblastic) leukemia is sometimes called ALL. Definition. Shortness of breath. poor appetite and weight loss. Hematologists and oncologists are specialists who treat people who have CML or other types of blood cancer. Hairy cell leukemia might not cause symptoms. without explicit limits). This is meaningful and important for anyone who has had breast cancer or anyone who has loved someone with breast cancer. Leukemia is a cancer of the blood cells. You or your doctor may be able. "to be") – am, is. Most people are diagnosed in this phase, and many do not have symptoms. These leukemias start in early forms of white blood cells called lymphocytes. Treatment of acute myelogenous leukemia depends on several factors, including the subtype of the disease, your age, your overall health and your preferences. ALL (acute lymphocytic leukemia) is the most common leukemia in children. Dream Meaning of Your Enemy. They can be classified as acute or chronic based on the rapidity of proliferation and myeloid or lymphoid based on the cell of origin. 7. CML is a clonal bone marrow stem cell disorder in which a proliferation of. Feline leukemia virus is a common disease that affects about 2% of cats in the United States. MCH stands for Mean Corpuscular Hemoglobin, and is a calculation of the average amount of hemoglobin contained in each of a person’s red blood cells. When there is a pathogen in your body, your immune system releases cells to fight it off and heal your body. A full or swollen belly from cancer cells in your liver or spleen. The caviar or fish eggs of sturgeon, cod, salmon, hake or tuna are considered a coveted dish and of the high cooking. When it causes symptoms, hairy cell leukemia might cause: A feeling of fullness in your belly that may make it uncomfortable to eat more than a little at a time. Leukemia cells also don't die when they should. It happens when healthy white blood cells ( lymphocytes) in your bone marrow mutate, or change, into cancerous cells that multiply and crowd out healthy blood cells and platelets. When the number of red blood cells is low, a child is anemic and may become pale, listless and easily tired. Exposure to radiation and chemicals such as benzene (found in unleaded gasoline) and other hydrocarbons. variants or chiefly British aleukaemia. leukaemia. This information is intended for people living in the United States who may have a primary language other than English. Night sweats. Bone marrow samples are obtained from 2 tests that are usually done at the same time: Bone marrow aspiration. These include: recurring infections. Summary. AML is characterised by an overproduction of immature white blood cells, called myeloblasts or leukaemic blasts. The blood’s cellular components originate primarily in the marrow of bones such as the sternum, iliac crest, and cranium. Instead, they are related to thrombocytopenia. Lymphocytes are a type of white blood cell involved in the body’s immune system. Risk Factors for Leukemia. A type of cancer that starts in the bone marrow, moves into the blood cells, and often metastasizes to other parts of the body including the liver, spleen, skin, brain, and spinal cord. Myelogenous (mai-uh-lOW-juh-nuhs) or myeloid leukemia develops from. Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. As an acute leukemia, ALL progresses rapidly and is typically fatal. 7 Not all sources, however, differentiate between male and female values; of these sources, values for both sexes. Abnormal results can indicate an issue in the bone marrow — where blood cells are made — or a variety of other disease. In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. Leukemia can be either acute or chronic. This medicine is available only with your doctor's prescription. Leukemia occurs due to a problem with blood cell production. Gender: Luke is traditionally the masculine form of the name. Leukemia. Infections. Getting a diagnosis. The main difference is that leukemia. ( lū-kē'mē-ă ), Progressive proliferation of abnormal leukocytes found in hemopoietic tissues, other organs, and usually in the blood in increased numbers. Some are more common in adults, while others impact children. But there are nuances. It happens when there are too many of the blood-forming cells called promyelocytes in the blood and bone marrow. Standard treatment usually helps in this phase. According to the Leukemia & Lymphoma Society, the “normal” range of white blood cells per microliter of. The bone marrow is where new blood cells are made. However, high immature granulocyte levels can also be normal during pregnancy and in newborns. 5. Bladder cancer. People with leukemia may develop rashes or bruises with no apparent cause, but these rashes may occur for several reasons and have many different appearances. Chronic lymphocytic leukemia. A headache. 2–5. This Review outlines a practical approach to assessing and managing polyclonal hypergammaglobulinaemia in adults. Your bone marrow produces white blood cells, red blood cells, and platelets. plaques. SEER is supported by the Surveillance Research Program (SRP) in NCI's Division of. Though the Carolina Beach Shack technically has just 35 seats, there were 500 people in attendance for the Fresh & Raw Tour, meaning the crowd — and great vibes — spilled out into the parking. These patients often have fever, poor appetite, and weight loss. 6. Night sweats. Reticulocytosis (increased RETICs) without anemia can be a key indicator that the bone marrow is responding to a need for increased red blood cell production. Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. Confusion: Leukemia can affect cognitive function, leading to confusion, disorientation, and difficulty concentrating or remembering things. Functional activity; All neoplasms are classified in this chapter, whether they are functionally active or not. A condition known as eosinophilia , high levels are described as mild (500 to 1,500 per microliter, ml, of blood), moderate (1,500 to 5,000 per ml), or severe (5,000 or more per ml). Other less common symptoms include: bone pain. The main types of acute leukemia are: Acute lymphocytic (lymphoblastic) leukemia (ALL): About 3 out of 4 childhood leukemias are ALL. Neutrophils are a type of white blood cell that help the body fight infections and heal injuries. It often describes the presence of immature cells such as myeloblasts or red blood cells with nuclei in the peripheral blood. Complete molecular. [1] ALL staging. There is the legacy of my twin sister and me continuing the mission of our mother’s work. Fatigue. ”. Soft tissue sarcomas can develop in soft tissues like fat. Chronic lymphocytic leukaemia is a rare type of cancer that affects the blood and bone marrow. Apply for VA health care, find out how to access services, and manage your health and benefits online. Dallas Cowboys WATCH: Dak Prescott to Brandin Cooks for Thanksgiving TD - NFL TrackerWe would like to show you a description here but the site won’t allow us. To me, Legacy has a double meaning. Please check back later, or browse on Shopify instead. Twitter; Wikitubia NetworkThis can cause more or abnormal bleeding and bruising, such as bleeding gums or nosebleeds. Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an important diagnostic clue. Leukemia symptoms vary, depending on the type of leukemia. Summary. A person's chances of surviving leukemia depend on a variety of factors, including their age, overall health, time of diagnosis. Leukemia may affect red blood cells, white blood cells, and platelets. The symptoms depend on the type of blood cell that’s being affected. It happens when healthy white blood cells ( lymphocytes) in your bone marrow mutate, or change, into cancerous cells that multiply and crowd out healthy blood cells and platelets. Fevers. a serious disease in which the body produces too many white blood cells 2. It explains the conditions. : leukemia in which the circulating white blood cells are normal or decreased in number. Being in remission doesn't mean you're finished with treatment. Leukemia is a cancer of the blood or bone marrow, which produces blood cells. Pain in the upper left portion of the abdomen, which may be caused by an enlarged spleen. It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma. According to the National Cancer Institute, B-cell acute lymphoblastic leukemia is the most common. leukemia noun. I love that Ethan was the only one to get it at first right after the idiot/imbecile/moron question. If acute myeloid leukemia (AML) continues to grow or returns after one type of treatment, other types of treatment might still be helpful. Learn more here. Signs and symptoms of acute lymphocytic leukemia may include: Bleeding from the gums. The production of abnormal leukocytes defines leukemia as either a primary or secondary process. Your symptoms can be caused by your low monocyte count or by other blood cell abnormalities, such as leukopenia (low white blood cells) or anemia. 15 U. It usually develops very slowly and does not always need to be treated straight away. They are measured by the number of white blood cells per cubic millimeter of blood (cells/mm3). Leukemia cells do not usually form tumors, but they can travel with the blood. Depending on the cause of the anemia, symptoms may include: Dizziness, lightheadness, or feeling like you are about to pass out. Those white blood cells crowd out the red blood cells and platelets. Although any subtype of. Exposure to agents used to cure or control other cancers, including radiation. Luke is an English form of the Latin Lucas, from the Greek name Loukas meaning "from Lucania," referring to the region in southern Italy. ALL is also called acute lymphoid leukemia or acute lymphoblastic leukemia. Key takeaways: The FVRCP vaccine protects cats against three highly contagious and dangerous diseases. The field of hematology/oncology can involve many. Luke's training, even if very basic, began when Ben handed Luke his father's lightsaber. Pain, including in your. Demanding and untrusting in relationships. 5 – 1. Benzene dissolves only slightly in water and will float on top of water. Leukemia, a malignant cancer of the blood, was named in 1847 by Dr. The JAK2 protein is particularly important for controlling blood cell production from hematopoietic (blood-forming) stem cells. irregular heartbeat. Leukemia definition: . The four main types of leukaemia are:Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer; it also strikes adults of all ages. Symptoms occur as the normal cells fail to perform their tasks, leading to infections and pain. Smoldering myeloma is a rare, pre-cancerous condition involving abnormal proteins and increased plasma cells in the bone marrow. Enlarge. 6 Cells multiply by dividing into two cells, making a new copy of the. Complete blood count (CBC) and peripheral blood smear: The CBC measures the numbers of red blood cells, white blood cells, and platelets. Capsule. “I’m really. Genes called oncogenes help cells grow, divide, and stay alive while tumor suppressor genes control cell division and cause cells to die at the right time. 1016/S2352-3026 (21)00056-9. A relapse is when cancer comes back after treatment. What does it mean to dream of Leukemia if you are a student? indicates a need to get away from cares and responsibilities. Thrombocytopenia (low platelets) can cause increased bruising or bleeding from the mouth or nose. Petechiae are considered a nonleukemic manifestation of leukemia, meaning that although petechiae and purpura can occur with leukemia, the skin marks are not directly related to the cell mutation that causes the underlying cancer. Apheresis. On this page. Luke is an English form of the Latin Lucas, from the Greek name Loukas meaning "from Lucania," referring to the region in southern Italy. Tissue damage from a burn injury or surgery. Knowing the type of disease you have is key to choosing the right. A decrease in the TLC count is referred to as leukopenia, and it will cause a decline in the body’s ability to fight diseases. Leukaemia (sometimes spelt as leukemia) is a cancer of the blood cells. But there is also the legacy of. Acute promyelocytic leukemia is a distinguished subset of acute myeloid leukemia which is characterized by fusion gene transcript PML-RAR-alpha and high cure rates with treatment. 9. Nausea, vomiting, diarrhea. Chronic lymphocytic leukaemia cannot usually be cured, but it can be managed with treatment. Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms related to cytopenias. As CML progresses, granulocytes take over your bone marrow and blood so that there’s no room for red blood cells, platelets, or healthy white blood cells. It slowly worsens over time, eventually leading to severe complications. Chronic myelomonocytic leukemia (CMML) is a type of leukemia, which are cancers of the blood-forming cells of the bone marrow. : leukemia resulting from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood. [ loo-ke´me-ah] a progressive, malignant neoplasm of the blood-forming organs, marked by diffuse replacement of the bone marrow development of leukocytes and their precursors in the blood and bone marrow. Depending on the cause of the anemia, symptoms may include: Dizziness, lightheadness, or feeling like you are about to pass out. Leukemia and lymphoma are both forms of blood cancer, but they affect the body in different ways. These ranges are based on the cell counts of healthy people of similar age and sex. 2. Leukemia is a broad term for cancers of the blood cells. Pain in bones/joints. Acute Lymphocytic Leukemia (ALL) in Adults. Awareness month: May. It has a sweet odor and is highly flammable. Night sweats. Contents Overview Symptoms and Causes Diagnosis. 26. These are not just symptoms of AML. Its vapor is heavier than air and may sink into low-lying areas. pain in your chest as well as your neck, shoulders, arms, and jaw. "to be") – am, is. CLL is typically found when you get a blood test for another reason. Chronic leukemia develops slowly and may need management over many years. Sometimes leukemia can spread, or metastasize. CML causes an increased number of white blood cells in the blood. Male sex. Acute leukemia is the most common cancer in children. These may be inherited, occur spontaneously, or arise due to certain environmental exposures. Infection rates are significantly higher (up to 30%) in cats that are ill or otherwise at high risk (see below). This article will help you to understand IGs and what low or high levels can mean. Early on, there are typically no symptoms. leukemia. The result may be a feeling of. It is the name given to a group of leukaemias that develop in the myeloid cell line in the bone marrow. Types of blood cancer vary based on the cells they affect as well as their incidence, method of diagnosis, and their prognosis. Acute myeloid leukemia (AML) is a type of acute leukemia. Acute myeloid leukemia (AML): This type of leukemia, also called acute myelogenous leukemia, acute myelocytic leukemia, or acute non. 0. We discuss the symptoms, causes, treatment, and prognosis with leukemia cutis. CLL staging. Summary. Hypernyms. Stages I and II are intermediate risk. Leukemia has several possible causes. Acute lymphoblastic leukemia (ALL) Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cells called lymphocytes. These are called intermediate soft tissue tumors. People with AML often have several non-specific (general) symptoms. Leukemia is a type of blood cancer that affects the blood cells and bone marrow, a tissue inside bones where blood cells and platelets are made. It is included in a routine blood panel known as a complete blood count (CBC). Acute monocytic leukemia ( AMoL, or AML-M5) [2] is a type of acute myeloid leukemia. Blincyto (Blinatumomab) Calaspargase Pegol-mknl. Leukemia is a type of cancer found in your blood and bone marrow and is caused by the rapid production of abnormal white blood cells. Fatigue. Canker Sores: Festering words held back by the lips. At MD Anderson’s Leukemia Center, the skin conditions we see most often in our patients fall into one of three major categories. S. When Leukemia cells cause swelling in the liver, kidneys, or spleen, these organs can press against the stomach. Posted: January 27, 2023. low platelet count, which may lead to increased bleeding after an injury, bleeding gums or nose, or blood in urine or bowel movements. Colors: Blue, marigold, and purple. tiredness and/or anaemia (pale complexion, weakness and breathlessness) repeated infections (mouth sores, sore throat, fevers, sweats, coughing, frequent passing of urine with irritation, infected cuts and scratches, and boils) increased bruising and bleeding. It typically happens when certain genes or chromosomes mutate (change). AML causes the body to produce too many myeloblasts, platelets, and red blood cells. It is accompanied by a reduced number of erythrocytes and blood platelets, resulting in anemia and increased susceptibility to. Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. In the latest Sidemen Sunday video, Who wants to be a Millionaire 2, Harry did Callux dirt, very dirty 😭Subscribe to the channel for more Sidemen clipsPh-Positive Acute Lymphoblastic Leukemia Until recently, Ph-positive ALL was very aggressive and difficult to treat. If the IgA blood test results are low, then this can be an indication that kidney failure has occurred. Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. Learn more. A sarcoma is a type of cancer that starts in tissues like bone or muscle. have palpitations (feel your heart is beating quickly). word-forming element in pathology meaning "condition of the blood," Modern Latin combining form of Greek haima (genitive haimatos) "blood," a word of no established etymology (replacing the usual IE word, represented in Greek by ear; possibly from uncertain PIE root *sei-"to drip" (compare Old High German seim "virgin honey," Welsh. Some. The meaning of LEUKEMIA is an acute or chronic disease in humans and other warm-blooded animals characterized by an abnormal increase in the number of white blood cells in the tissues and often in the blood. Read on to learn about the four most common types of leukemia. A dacrocyte (or dacryocyte) is a type of poikilocyte that is shaped like a teardrop (a "teardrop cell"). A low WBC count may be due to chemotherapy, a viral infection, a toxic reaction, or a process in the. The meaning of ACUTE LYMPHOBLASTIC LEUKEMIA is lymphocytic leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and. It starts in your bone marrow, the soft inner parts of bones. 1510 eimí (the basic Greek verb which expresses being, i. e. Depending on the techniques used, such as morphology by manual microscopy, immunohistochemistry, and flow cytometry, blasts are recognized and enumerated by different characteristics and. Radiation exposure (i. This was shortened to Luke in English. These stem cells are located in the bone marrow (the spongy. Leukemia. Anemia occurs when the number of red blood cells is lower than normal. Some blood disorders cause few symptoms, while others are responsible for more. Never trust a Lukeemia. The Janus kinase 2 (JAK2) gene directs cells to make the JAK2 protein, which stimulates cell growth and division. AML affects myeloid cells, which are precursor cells that form into specific blood cells. Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. B-cell acute lymphoblastic leukemia is a type of acute lymphoblastic leukemia (ALL). Fever, chills, night sweats and weight loss, which are collectively known as constitutional or “B” symptoms, are also common in APL. Putting it together. Other causes include nephritic syndrome, some types of leukemia and common variable immunodeficiency. signs of bleeding due to low platelet levels. Abstract. Long-term exposure to benzene.